CCRAS – CSMCARI, Chennai

Ongoing and Completed Research Projects

S. no

Department

Ongoing

Completed

1.

Biochemistry

Anti-cancer activity of Chaulmoogra oil and Shwetha Sarshapa churna in the treatment of epidermal carcinoma of skin in experimental mice.

1.A biochemical role of AYUSH-PTK, an Ayurvedic formulation against anti-tubercular drug-induced hepatotoxicity in rats (2020-2022)

2. Anti-atherosclerotic activity of Hirdayarnava rasa on animal model (2018-2020)

3.Biochemical studies on Premna integrifolia Linn. in high-fat diet-induced atherosclerosis model rats (2014-2016)

2

Chemistry

1. Phytochemical investigation of hydro-alcoholic extractives with different

ratios of selected Kvatha formulations (ICH077)

2. Development of quality standards & SOP with markers-based analysis and

shelf-life study of four medicinally important classical Ayurvedic

formulations (ICH069)

3. Development of quality standards, Estimation of markers, and shelf-life

studies of Kvatha churna formulations (ICH068)

4. Comparative Phytochemical Evaluation of Ht.Wd with small branches,

leaves, and stem bark of common medicinal plants used in Ayurveda

(ICH078)

5. Development of Quality Standards, Estimation of Markers and accelerated

shelf-life studies of Guducyadi, Caturbhadra and Amrtottara kvatha churna

formulations (ICH079)

6. Unraveling the Phytochemical Landscape of Selected Ayurvedic Tailas

Through Advanced Chromatographic Profiling

Chemical Profiling of Seven Ayurvedic Plant Drugs (Stem bark/Root and

Small branches/Aerial parts) by HPLC/GC-Ms/LC-MS and other related

Techniques

2. Development of Standards for Musk-Raw Drug of Animal Origin used in

ASU Drugs

3. Effect of Shodhan procedures on Chemical profiling of Ayurvedic drugs

of plant origin (Visa Drvya) mentioned under Schedule E-1 of D&C Act

4. Qualitative and Quantitative analysis of markers/PRS & Shelf-life study of

Ayush -D Tablet and Ayush PE eye drop formulations (prepared trial

drugs)

5. Qualitative and Quantitative analysis of Markers/PRS & Shelf-life studies

of Carctol – S Capsules, Ayush-SL Tablets and Ksharasutra formulations

(prepared trial drugs)

6. Development of quality standards of Indian Indigenous medicinal plants

and preparation of monographs thereon

7. Qualitative Authentication of selected market samples of crude drugs

available in various markets of India

8. To establish the best procurement time for certain herbs by analyzing the

seasonal variation in bioactive secondary metabolites with qualitative

HPLC

9. Evaluation of Seasonal and Geographical Variation on

Phytoconstituents/Marker Compounds in Selected Ayurvedic Medicinal

Plants

10. Estimation of Calcium and Trace Minerals & Metals in Sudhavarga drugs

of Ayurveda

11. Isolation of marker compounds from Ayurvedic Plants and Development

of Marker Compound Library

12. Pharmaceutical Development and Standards for Formulation AYUSH-64

13. Nutritional profiling, Estimation of marker of Balya drugs

14. Isolation of Marker Compounds and Development of Marker Compound

Library from four Selected Ayurvedic Medicinal Plants (Kancanara,

Asthisrnkhala, Puskara & Lajjalu)

15. Evaluation of Seasonal and Geographical variation of

phytoconstituents/marker compounds in selected Ayurvedic Medicinal

Plants

3.

Pharmacology

1. Cardioprotective Effect of Pushkara Guggulu on Experimentally Induced Myocardial Infarction in Rats

1. Acute and Chronic (180 days) repeated dose oral toxicity study of Nimbatitkam

1. Acute and 180-days repeated dose oral toxicity study of Ayush Balrakshak Lehyam

Collaborative Projects

1. Development of Madhuca longifolia (Flower) based food recipe (Product development) and its nutritional,toxicity, efficacy and bioavailability studies

1. Toxicity profile of Tribhuvana Kirti Rasa in experimental animals.

1. Development of Opuntia elatior (fruit) based food recipes (product development) and its         nutritional, toxicity, efficacy and bioavailability studies

1. Effect of Haritkadi yoga on middle cerebral artery occlusion ischemic-reperfusion injury and its safety in rats.

1. Acute and 90 days repeated dose oral toxicity study of Coded drug AYUSH-PK Avaleha

1. Acute and 90 days repeated dose oral toxicity study of Coded drug AYUSH-SDM.

1. Development of Drug Master file and Dossier on fruit of Emblica officinalis for promising medicinal plants based on leads for Ayurveda and contemporary research. Pharmacology part.

1. Evaluation of Sveta Parpati for its curative and preventive action in Urolithiasis experimental study in rats.

1. Preclinical Evaluation (Toxicity and efficacy profile) of an Ayurvedic herbal formulation Vaisvanara Churna used in the treatment of Rheumatoid arthritis.

1. Acute and 90 days repeated dose oral toxicity study of Coded drug AYUSH-HR

1. In vitro and in vivo nephro protective evaluation of AYUSH K1 extract.

1.   In-vitro and in-vivo evaluation of anti-migraine activity of AYUSH-M3.

1. Safety and anti-obesity activity of Tryusanadi guggulu in experimental animals.
2. Acute and chronic (180 days) oral toxicity study of coded drug AYUSH RP

4.

Pharmacognosy/ Botany

1. Development of Quality standards for Useful Parts of Selected Medicinal Plants of Ayurveda (IPS0033)

 2. Development of Quality Standards of Elsholtzia Species and assessment of Efficacy in Gastric Inflammatory Conditions (CPS0002)


 3. Medico-Ethnobotanical Surveys in Kolli Malai and Pacha Malai and preparation of Monographs. (IBO0066)

 4. Development of a Rapid and Cost-Effective Primer-Based Tool for Correct Species Determination of Some Commonly Traded Herbal Drugs. (IBO0080)

1. Developing Pharmacognostical Standards for some Ambiguous Ayurvedic Drugs (Sandigdha Dravyas) appearing in the Ayurvedic Formularies, Parts I to III. (IPS0013)

2.Pharmacognostical Evaluation of Medicinal Plants cited in Ayurvedic Formulary of India excluding the plants mentioned in Ayurvedic Pharmacopoeia of India- Part –I

3.Pharmacognostical Evaluation of Medicinal Plants cited in Ayurvedic Formulary of India excluding the plants mentioned in Ayurvedic Pharmacopoeia of India- Part –II. (IPS0014)

4 .Photographic Atlas on Macro-microscopic Characteristics of Medicinal Plants Listed in Ayurvedic Pharmacopoeia of India, Part-I, Volume – II. (IPS0019)

5.Development of drug Master file and dossier on Fruits of Emblica officinalis (Farm: Phyllanthaceae) for Important Promising Medicinal Plants Based on Leads from Ayurveda & Contemporary Research. (IPS0027)

6.Development of Quality Standards of Selected Extra-pharmacopoeial Drugs (Anukta Dravyas) Used in Local Health Traditions Collected from Different Regions of India. (IPS0028)

7.Anthology of Pharmacognostical Research Outcomes of CCRAS on Selected Medicinal Plants of Ayurveda.

8. Development and Digitalization of Authentic Ayurvedic Raw Drugs and Herbarium for the Medicinal Plants Appearing in Ayurvedic Formularies of India in Mandatory Drug Testing Laboratories of CCRAS. (IPS0027)

5.

Ayurveda/ Pharmacy

1. A Cross-sectional Survey to study the distribution pattern of different prakriti types across India – A multi centric study
2. Implementation and Evaluation of a Health Care Model Using Structured Yoga and Lifestyle Interventions for Wellness Promotion and Chronic Disease Risk Reduction: A Health Systems Research Study

1. Ethno-medicinal Survey of Plants Used in Various Diseases by Tribe of Thandarai, Chengalpattu, Kancheepuram District, Tamilnadu
2. Developing Quality Standards for selected Extra-pharmacopoeial drugs collected from Irula tribes of Thandarai, Kancheepuram District, Tamilnadu
3. Documentation of Life Profiles of Luminaries of Ayurveda – Vaidyaratna Captain G Srinivasa Murthy
4. Documentation of Life Profiles of Luminaries of Ayurveda – Ms Savita Satakopan
5. Documentation of Life Profiles of Admirable Personalities to Transform Ayurveda (APTA)’ – Padmashri Dr. V. Narayanaswamy
6. Documentation of Life Profiles of Luminaries of Ayurveda – Vaidyaratna N Rama Varier
7. Documentation of Life Profiles of Admirable Personalities to Transform Ayurveda (APTA)’ – Aryavaidyan P V Raghava Varier
8. Developing Quality Standards for selected Arka Formulations

6.

Microbiology

1.Isolation and Identification of Endophytic Microorganisms from the stem barks used in Ayurveda (Panchavalkala) and Evaluation of their Antimicrobial, antioxidant and antibiofilm activities

2.    Anti-mycobacterial             screening of selected medicinal plants against common pathogenic       strains of Non-Tuberculous Mycobacteria (NTM)

1. Antibacterial Activity of selective Ayurveda formulations against Gastrointestinal infection, Respiratory infection and Urinary Tract infection-causing bacteria